LC2CAM Panel Discussion on Careers

submitted by: icamvid

A panel of scientists discusses career paths at the LC2CAM 2008 conference.

Genes and Cells that Determine the Lifespan of C. elegans - Part 2: The Regulation of Aging by Signals from the Reproductive System, and, also, a Link Between Aging and Tumor Growth (37:16)

submitted by: video_collector
Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other signals. In the nematode C. elegans, in which many key discoveries about aging were first made, the aging process is subject to regulation by food intake, sensory perception, and signals from the reproductive system. Changing genes and cells that affect aging can lengthen lifespan by six fold, and...

Polyketide Biosynthesis: The Erythromycin Example - Part 3: Enzymology of Erythromycin Polyketide Biosynthesis (42:11)

submitted by: video_collector

In the final part, the enzymology of the erythromycin polyketide synthase is discussed.

Polyketide Biosynthesis: The Erythromycin Example - Part 2: Impact of Genetics and Molecular Biology on Understanding and Engineering Erythromycin Biosynthesis (22:44)

submitted by: video_collector

In the second part, the contributions of genetics and molecular biology on investigations into erythromycin biosynthesis are summarized. The impact of these fields on biosynthetic engineering is also explained.

Computational Protein Design Part 2: Designing Protein Libraries and an Example of Making a Better Fluorescent Protein (33:50)

submitted by: video_collector
In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high...

Genes and Cells that Determine the Lifespan of C. elegans - Part 1: An Evolutionarily-Conserved Regulatory System for Aging (42:46)

submitted by: video_collector
Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other signals. In the nematode C. elegans, in which many key discoveries about aging were first made, the aging process is subject to regulation by food intake, sensory perception, and signals from the reproductive system. Changing genes and cells that affect aging can lengthen lifespan by six fold, and...

Polyketide Biosynthesis: The Erythromycin Example - Part 1: Overview of Polyketides and Polyketide Biosynthesis (34:10)

submitted by: video_collector

In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented.

For further informaton see: http://www.ascb.org/ibioseminars/Khosla/Khosla1.cfm

Design and Testing of Protein Combinatorial Libraries - Part 1: Introduction to Protein Design by Computation (31:09)

submitted by: video_collector
In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high...

Two-photon excitation microscopy

submitted by: diaspro

Two-photon excitation microscopy as a tool for studying biological systems.