Crevicular fluid biomarkers and periodontal disease progression

submitted by: Janet Kinney
AIM: Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP). MATERIALS AND METHODS: 100 individuals participated in a 12-month longitudinal investigation and categorized into 4 groups according to their periodontal status. GCF, clinical parameters, and saliva were collected bi-monthly. Sub-gingival plaque and serum were collected bi-annually. For 6 months, no periodontal treatment was provided. At 6-months,...
Authors: Thomas Braun, William Giannobile, Janet Kinney, Thiago Morelli, Min Oh, Christoph Ramseier, James Sugai

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Metabolic disorder: Find it early, save a child.

submitted by: Clare Hovan
Skipping across the playground. Trotting off to school. Flying kites in the park. The researchers at the Centre Hospital Universite De Sherbrooke (CHUS) in Quebec need not look far to see reminders of why their work is so important. Early detection of metabolic disorders in newborns offers a better chance for preventing such serious conditions as mental retardation, metabolic acidosis, even death. Listen to how the CHUS urine screening program has made a difference in helping Quebec’s...

Time-resolved monitoring of the transcriptome of MCF-7 breast cancer cells during the emergence of cisplatin resistance

submitted by: martin_unibonn

Gene expression measurement during treatment with Cisplatin for breast cancer.

Alzheimer's Disease

submitted by: alex01
Z. Khachaturian, PhD. - New approaches to the therapy of Alzheimer’s disease (AD) are discussed in video interviews of this series. According to Z. Khachaturian (Potomac, MD) substantial progress has been made during the last 10 years in our understanding of pathogenesis of Alzheimer’s disease as well as in the discovery of biomarkers and therapeutic approaches. In addition to cholinergic drugs, inhibitors of plaque formation have been discovered, but the currently available...