Emergence of Azole Resistance in Aspergillus fumigatus and Spread of a Single Resistance Mechanism.

submitted by: nelleke
Background Resistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive aspergillosis. The prevalence of azole resistance in A. fumigatus is unknown. We investigated the prevalence and spread of azole resistance using our culture collection that contained A. fumigatus isolates collected between 1994 and 2007. Methods and Findings We investigated the prevalence of itraconazole (ITZ) resistance in 1,912 clinical A. fumigatus...
Authors: Eveline Snelders, Henrich a. l. van der Lee, Judith Kuijpers, Anthonius j. m. m. Rijs, János Varga, Robert a. Samson, Emilia Mellado, A. rogier t. Donders, Willem j. g. Melchers, Paul e. Verweij