The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase

submitted by: tracyanthony
Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eIF2 by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene expression to alleviate cell injury. This study addressed the importance of GCN2 for the immune system to adapt to amino acid starvation by ASNase. GCN2+/+ and GCN2-/- mice were injected once daily with ASNase or saline for up to 7 d....
Authors: Carla Aldrich, Ronald Wek, Rachel Reinert, Judy Cundiff, Piyawan Bunpo, Tracy Anthony