Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 2: The apicomplexan plastid: Something old, something new, something borrowed, something green (37:11)

submitted by: video_collector
Antibiotics are effective because they kill bacteria without harming humans and other eukaryotes (organisms with cells that contain nuclei). So why are the eukaryotic parasites responsible for malaria and toxoplasmosis killed by drugs like clindamycin? Multidisciplinary studies integrating molecular genetics, cell biology, biochemistry, pharmacology and computational genomics reveal that such drugs target an unusual organelle. The "apicoplast" was acquired when an ancestral organism 'ate' a...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles by David S. Roos, May 2008 - Part 1: How to build a parasite

submitted by: video_collector
There are more than 5000 species of single-celled eukaryotes in the biological phylum known as the Apicomplexa, including the parasites responsible for malaria, neurological birth defects, and opportunistic infections associated with HIV/AIDS. These ancient protozoa provide a unique window into the evolution of subcellular organelles that have long fascinated cell biologists. Familiar features help to elucidate the origins, functions and design parameters for the secretory pathway,...