Bacterial Inclusion Bodies Contain Amyloid-Like Structure

linked profile(s): Lei Wang
submitted by: apryl
Protein aggregation is a process in which identical proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally classified as amorphous, lacking any long-range order, or highly ordered fibrils. Protein fibrils can be composed of native globular molecules, such as the hemoglobin molecules in sickle-cell fibrils, or can be reorganized β-sheet–rich aggregates, termed amyloid-like fibrils. Amyloid fibrils are associated with several...
Authors: David Eisenberg, Samir K Maji, Roland Riek, Michael R Sawaya, Lei Wang

Antibody-protein interactions: benchmark datasets and prediction tools evaluation

linked profile(s): juliap
submitted by: apryl
Background The ability to predict antibody binding sites (aka antigenic determinants or B-cell epitopes) for a given protein is a precursor to new vaccine design and diagnostics. Among the various methods of B-cell epitope identification X-ray crystallography is one of the most reliable methods. Using these experimental data computational methods exist for B-cell epitope prediction. As the number of structures of antibody-protein complexes grows, further interest in prediction...
Authors: Julia v Ponomarenko, Philip e Bourne