SSRIs Video Consult

submitted by: Rxconsultnow

This video will provide information on the Selective Serotonin Reuptake Inhibitor antidepressants, specifically fluoxetine and sertraline.

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A Generalist's Guide to Treating Patients With Depression With an Emphasis on Using Side Effects to Tailor Antidepressant Ther

submitted by: mcgheekkm

Dr. J. Michael Bostwick, Professor of Psychiatry at Mayo Clinic in Rochester, MN, discusses his article on a generalist's guide to treating patients with depression with an emphasis on using side effects to tailor antidepressant therapy.

Cytokines and Neutrophins in Neuroprotection

submitted by: alex01
Dr. Michael Spedding published recently a review on the role of cytokines and neurotrophins in disease. Neurotrophins (e.g. BDNF) have beneficial effects on neuronal plasticity and brain metabolism. Inflammatory cytokines (e.g. IL1beta)oppose the effects of neurotrophins. Both, neurotrophins and cytokines are targets for the development of new drugs affecting central nervous system. Brain-derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophic factor. Interleukin 1beta...

Treatment of Depression

submitted by: alex01

P. Skolnick, PhD - Depression is a highly heterogenous disorder. Currently available therapy is not sufficiently effective. DOV Pharmaceuticals has triple (serotonin, norepinephrine, dopamine) uptake inhibitors in clinical evaluation. They are expected to be effective in a larger proportion of patients and have more rapid onset of action. They also reduce body weight and plasma triglycerides.