Sodium Channels and Pain

submitted by: alex01

S. Waxman, MD, PhD. - Medical need for new analgesics is discussed by S. Waxman (Yale University) who evaluated the role of selective subtypes of sodium channels, particularly 1.7 and 1.8 subtypes, in the perception of pain. There is an unmet medical need for drugs to treat chronic pain and inhibitors of
selective sodium channels are in development as novel analgesics.

Therapies for Multiple Sclerosis

submitted by: alex01

J. Kocsis, PhD. - The current approaches to the therapy of multiple sclerosis are reviewed by J. Kocsis (Yale University). His research emphasizes remyelination as an approach to the therapy of multiple sclerosis and spinal cord injury.

Alzheimer's Disease

submitted by: alex01
Z. Khachaturian, PhD. - New approaches to the therapy of Alzheimer’s disease (AD) are discussed in video interviews of this series. According to Z. Khachaturian (Potomac, MD) substantial progress has been made during the last 10 years in our understanding of pathogenesis of Alzheimer’s disease as well as in the discovery of biomarkers and therapeutic approaches. In addition to cholinergic drugs, inhibitors of plaque formation have been discovered, but the currently available...