Vinculin minds the endothelial gap

submitted by: JCB
The adhesions between endothelial cells transiently remodel in response to angiogenic growth factors and inflammatory cytokines. Huveneers et al. reveal that remodeling takes place at a subset of adhesions called focal adherens junctions, which recruit the mechanosensory protein Vinculin to resist tension from the actomyosin cytoskeleton and avoid excessive disruption during the remodeling process. This biosights episode presents the paper by Huveneers et al. from the March 5, 2012, issue of...