Ten Common Questions (and Their Answers) About Off-Label Drug Use.

submitted by: WentzMR
Dr. Christopher Wittich, a General Internist at Mayo Clinic in Rochester, MN, discusses his article appearing as an Online First publication and in the October 2012 print issue of Mayo Clinic Proceedings, where he describes 10 common questions regarding off-label drug use and gives practical guidelines and clinical scenarios for where and when this routine practice is acceptable. Available at: http://www.mayoclinicproceedings.org/article/S0025-6196(12)00683-0/fulltext Visit the Mayo Clinic...

Treatment of Epilepsy

submitted by: alex01
Michael Rogawski (University of California, Davis) summarizes his research on the antiepileptic activity of neurosteroids (e.g. ganaxolone, allopregnanolone). They are allosteric modulators of GABAA receptors and are active in many models of epilepsy. They are expected, however, to be most effective in catamenial epilepsy, infantile spasms or adult partial seizures. National Institutes of Health (NIH) is currently sponsoring a clinical trial of progesterone (precursor of allopregnanolone)...