Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins

Being Overweight or Obese Is Associated with Lower Prevalence of Anemia among Colombian Women of Reproductive Age

submitted by: kasiek
Overweight and micronutrient deficiencies have manifested in the same individuals. This study investigated the association among iron deficiency (ID), anemia, and weight status among nonpregnant Colombian females aged 13-49 y (n = 3267). Data from the 2005 National Survey of the Nutrition Situation were used. The prevalence of ID (plasma ferritin <12.0 ?g/L; individuals with CRP >0.012 g/L excluded) and anemia (altitude-adjusted hemoglobin <120 g/L) was estimated separately. The...
Authors: Katarzyna Kordas, Zulma Centeno, Helena Pachon, Ana Zulema Soto

Clinical Pearls in General Internal Medicine

submitted by: mcgheekkm

Dr. John Bundrick, a consultant in medicine at Mayo Clinic in Rochester, MN, discusses his article "Clinical Pearls in General Internal Medicine," ( Available at: ) which appears in the January 2011 issue of Mayo Clinic Proceedings.

Myelodysplastic Syndromes—Many New Drugs, Little Therapeutic Progress

submitted by: mcgheekkm

Dr. Ayalew Tefferi, professor of Hematology and Medicine at Mayo Clinic, discusses his article entitled "Myelodysplastic Syndromes: Many New Drugs, Little Therapeutic Progress, which appears in the November 2010 issue of Mayo Clinic Proceedings (Available at: