High School Football and Risk of Neurodegeneration: A Community-Based Study

submitted by: WentzMR
Dr. Rodolfo Savica, Assistant Professor of Neurology at Mayo Clinic in Rochester, MN, discusses his article appearing in the April 2012 issue of Mayo Clinic Proceedings which finds no increased incidences of Dementia, ALS, or Parkinson's disease in persons who played high school football from the mid-1940's to the mid-1950's. Although this is excellent news for that population, further studies are needed to corroborate results in more recent high school sports participants, given the...

Cytokines and Neutrophins in Neuroprotection

submitted by: alex01
Dr. Michael Spedding published recently a review on the role of cytokines and neurotrophins in disease. Neurotrophins (e.g. BDNF) have beneficial effects on neuronal plasticity and brain metabolism. Inflammatory cytokines (e.g. IL1beta)oppose the effects of neurotrophins. Both, neurotrophins and cytokines are targets for the development of new drugs affecting central nervous system. Brain-derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophic factor. Interleukin 1beta...