Methylphenidate Decreased the Amount of Glucose Needed by the Brain to Perform a Cognitive Task

submitted by: noravolkow
The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is still unclear how they work or why they improve performance in some individuals but impair it in others. To test the hypothesis that stimulants enhance signal to noise ratio of neuronal activity and thereby reduce cerebral activity by increasing efficiency, we measured the effects of methylphenidate on brain glucose utilization in healthy adults. We...
Authors: Nora d. Volkow, Joanna s. Fowler, Gene-jack Wang, Frank Telang, Jean Logan, Christopher Wong, Jim Ma, Kith Pradhan, Helene Benveniste, James m. Swanson