Validation of an In Vitro Digestive System

submitted by: KopfBolanz
The digestive process transforms nutrients and bioactive compounds contained in food to physiologically active compounds. In vitro digestion systems have proven to be powerful tools for understanding and monitoring the complex transformation processes that take place during digestion. Moreover, the investigation of the physiological effects of certain nutrients demands an in vitro digestive process that is close to human physiology. In this study, human digestion was simulated with a 3-step...
Authors: KA Kopf-Bolanz, F Schwander, M Gijs, G Vergères, R Portmann, L Egger

Maximum-Likelihood Model Averaging To Profile Clustering of Site Types across Discrete Linear Sequences

submitted by: JeffreyTownsend
A major analytical challenge in computational biology is the detection and description of clusters of specified site types, such as polymorphic or substituted sites within DNA or protein sequences. Progress has been stymied by a lack of suitable methods to detect clusters and to estimate the extent of clustering in discrete linear sequences, particularly when there is no a priori specification of cluster size or cluster count. Here we derive and demonstrate a maximum likelihood method of...
Authors: Zhang Zhang, Jeffrey P. Townsend