Childhood Leukemia: Most Common Childhood Cancer

submitted by: mdanderson

Childhood leukemia is the most common childhood cancer with more than 3,500 children in the U.S. diagnosed each year. Patrick Zweidler-McKay, M.D., Ph.D., Assistant Professor at The University of Texas MD Anderson Cancer Center Children’s Cancer Hospital, talks about symptoms, diagnoses and treatment of this blood disease. Zweidler-McKay also discusses health problems that may occur decades after treatment and encourages long term follow-up doctor visits.

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase

submitted by: tracyanthony
Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eIF2 by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene expression to alleviate cell injury. This study addressed the importance of GCN2 for the immune system to adapt to amino acid starvation by ASNase. GCN2+/+ and GCN2-/- mice were injected once daily with ASNase or saline for up to 7 d....
Authors: Carla Aldrich, Ronald Wek, Rachel Reinert, Judy Cundiff, Piyawan Bunpo, Tracy Anthony