AMPA Ligands in Neuroprotection

Michael Spedding (Institute Internatinales Servier, Paris, France) described how neuroprotection can be achieved by... » More

Michael Spedding (Institute Internatinales Servier, Paris, France) described how neuroprotection can be achieved by either by blockade or by stimulation of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors. Low threshold AMPA receptor stimulation leads to the release of BDNF (brain-derived neurotrophic factor) which is neuroprotective. Blockade of AMPA receptors reduces excitotoxicity leading to neuroprotection. BDNF is a major activity-dependent neurotrophic factor affecting neuronal plasticity and brain metabolism. Drugs that resemble BDNF or release BDNF are potentially useful neuroprotective agents. « Hide