Pubcasts in Physiology/Fisiología

A semaphorin code defines subpopulations of spinal motor neurons during mouse development.
In the spinal cord, motor neurons (MNs) with similar muscle targets and sensory inputs are grouped together into motor pools. To date, relatively little is known about the molecular mechanisms that...

Crystalluria and its possible significance. A patient-control study.
The significance of crystalluria in the diagnosis and prognosis of urolithiasis remains a controversial subject in the current urological literature. In this study, in addition to the standard...

LOCATE: a mouse protein subcellular localization database
We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence...

Multipolar representation of protein structure
Background That the structure determines the function of proteins is a central paradigm in biology. However, protein functions are more directly related to cooperative...

Pericardial pathology 900 years ago: A study and translations from an Arabic medical textbook
This is a study and translation of the section on pericarditis in Al Taisir book written by the Muslim physician Ibn Zuhr (Avenzoar) who lived and practiced in Eshbeelia (nowadays Seville,...

Phylogeny determined by protein domain content
A simple classification scheme that uses only the presence or absence of a protein domain architecture has been used to determine the phylogeny of 174 complete genomes. The method correctly divides...

Structural Evolution of the Protein Kinase–Like Superfamily
The protein kinase family is large and important, but it is only one family in a larger superfamily of homologous kinases that phosphorylate a variety of substrates and play important roles in all...

The Association of Tetrameric Acetylcholinesterase with ColQ Tail: A Block Normal Mode Analysis
Acetylcholinesterase (AChE) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. In physiological conditions, AChE exists...

The functional anatomy of the uretero-vesical junction. A historical review.
This paper evaluates the progress of anatomy and dissection during the Middle Ages both in Europe and in the Muslim World. For that purpose, the functional anatomy of the ureterovesical junction...

The PDZ Domain as a Complex Adaptive System
Specific protein associations define the wiring of protein interaction networks and thus control the organization and functioning of the cell as a whole. Peptide recognition by PDZ and other...