A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

apryl — Sun, 02 Dec 2007 19:36:08 -0800

In the spinal cord, motor neurons (MNs) with similar muscle targets and sensory inputs are grouped together into motor pools. To date, relatively little is known about the molecular mechanisms that control the establishment of pool-specific circuitry. Semaphorins, a large family of secreted and cell surface proteins, are important mediators of developmental processes such as axon guidance and cell migration. Here, we used mRNA in situ hybridization to study the expression patterns of semaphorins and their receptors, neuropilins and plexins, in the embryonic mouse spinal cord.

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A semaphorin code defines subpopulations of spinal motor neurons during mouse development.