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Protein Prediction 2 - Winter Semester 2011 / 2012


This lecture continues the 'Protein Prediction' lecture. Topics will include (but not be limited to): * Predicting protein function using sequence: sequence alignments, multiple sequence alignments, motifs, domain assignment, annotation transfer by homology, ab initio predictions. * Predicting protein function using structure: structural alignments, structural motifs, annotation transfer via structure similarity. * From structure prediction to function prediction: comparative modeling; prediction of: secondary structure, hydrophilicity profiles, solvent accessibility, transmembrane segments, disordered regions, contact maps, functional residues; template free modeling. * Machine learning.

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