The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin cytoskeleton to the plasma membrane. Roubinet et al. describe how Moesin's localization and activity is regulated over the course of the cell cycle by two different pathways that control Moesin phosphorylation and phosphoinositide synthesis. This biosights episode presents the paper by Roubinet et al. from the October 3, 2011, issue of The Journal of Cell Biology, and includes an interview with senior author Sébastien Carréno (University of Montreal, Canada). Produced by Caitlin Sedwick and Ben Short.
Read the related article online at: http://jcb.rupress.org/content/195/1/99.full
« Hide
