Translational Biology as described in http://www.bcm.edu/tbmm form Baylor College of Medicine Experimental nonhuman and nonclinical studies conducted with the intent of developing principles for the discovery of new therapeutic strategies. Clinical investigations that provide a biological foundation for the development of improved therapies. The definition of guidelines for drug development or for the identification and validation of clinically relevant biomarkers. Any clinical trial initiated in accordance with the above goals, and basic science studies that define the biological effects of disease pathogenesis and therapeutics in humans. from Horg et al., Nature Medicine 11:705