Pubcasts in Universal Science

LOCATE: a mouse protein subcellular localization database
We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence...

Methylphenidate Decreased the Amount of Glucose Needed by the Brain to Perform a Cognitive Task
The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is still unclear how they work or why they improve...

Order in Spontaneous Behavior
Brains are usually described as input/output systems: they transform sensory input into motor output. However, the motor output of brains (behavior) is notoriously variable, even under identical...

Rethinking proteasome evolution: two novel bacterial proteasomes.
The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary....

Stability of response characteristics of a Delphi panel: application of bootstrap data expansion
Background Delphi surveys with panels of experts in a particular area of interest have been widely utilized in the fields of clinical medicine, nursing practice, medical...

Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors
Background The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for...