Plenary talk by David Lipman (NCBI). Over the last 30 years, advances in DNA sequencing technology and other high throughput methods have led to exponential growth in biomedical data. Right from the beginning, the leadership at the National Institutes of Health and other major funding agencies promoted explicit policies on data sharing and also supported centralized databases for molecular data. The biomedical research community have become intensive users of these resources but also directly contribute their own data - often before publication. This virtuous circle has led to an increased rate of biological discovery. Fortuitously, these advances have taken place during the rise of the internet, further promoting researchers' ability to access and analyze scientific
data. Indeed, the Web has dramatically enhanced the ability of all sectors of society to communicate and to share information. Despite the progress in data sharing and analysis, and despite the increased capabilities of the Web, our ability to communicate biomedical knowledge has not kept pace. By communicating knowledge I mean publishing biomedical research papers, reference materials and educational content. I will discuss these issues and suggest some possible solutions.