Neglected Tropical Diseases Community

Adapting the DOTS framework for tuberculosis

ahyde — Fri, 06 Jun 2008 02:41:00 -0700

In an interview about his forthcoming paper, Donald Enarson (from The International Union against Tuberculosis and Lung Disease in Paris) discusses how the DOTS paradigm could be adapted for controlling diseases such as diabetes in resource-poor countries.

Neglected Tropical Diseases Community

MSI-CIEC: Computational Science and Drug Discovery

foxsdengcf — Fri, 15 Feb 2008 13:08:59 -0800

Andy McCammon discusses "Computational Science and Drug Discovery" at The Minority-Serving Institutions Cyberinfrastructure Institute (MSICI2) Preliminary Program at the San Diego Supercomputing Center, University of California San Diego La Jolla, California | June 26-29, 2006

MSI-CIEC: MSI Cyberinfrastructure Empowerment Coalition

Functional and Structural Insights Revealed by Molecular Dynamics Simulations of an Essential RNA Editing Ligase in Trypanosoma

apryl — Sun, 02 Dec 2007 17:14:29 -0800

RNA editing ligase 1 (TbREL1) is required for the survival of both the insect and bloodstream forms of Trypanosoma brucei, the parasite responsible for the devastating tropical disease African sleeping sickness. The type of RNA editing that TbREL1 is involved in is unique to the trypanosomes, and no close human homolog is known to exist. In addition, the high-resolution crystal structure revealed several unique features of the active site, making this enzyme a promising target for structure-based drug design.

tRNA on Ribosome

Drug Discovery: African Sleeping Sickness

apryl — Thu, 30 Aug 2007 15:32:23 -0700

Originally posted by SDSC on SDSC's CI Channel at: www.cichannel.org
Rommie Amaro, Computational and Theoretical Biophysical Chemist, discusses how she uses the resources at SDSC to conduct her drug discovery research on African Sleeping Sickness

CI Channel Video Community