ASCORE provides a metric that measures likelihood of matching site-determining ions by chance.
It greatly reduces the need for manual validation, and provides researchers the capability to accurately report the minimum number of sites identified.
Description:
Analyzing phosphopeptides using proteomics mass spectrometry is challenging, especially for large-scale data sets. The problem and solution is...
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Analyzing phosphopeptides using proteomics mass spectrometry is challenging, especially for large-scale data sets. The problem and solution is discussed by Dr. Sean Beausoleil (Harvard Medical School), who is the co-inventor of the ASCORE algorithm for phosphorylation site localization.