Topological Network Alignment Uncovers Biological Function and Phylogeny
- Conference:
- ISMB/ECCB 2009
- Abstract:
- Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments in comparative proteomics use information external to the networks, such as protein sequence, because no good algorithm for purely topological alignment has yet been devised. We present GRAAL (GRAph ALinger), an algorithm based solely on network topology, that can be used to align any two networks, not necessarily biological ones.
- Description:
- Biological network alignment.
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