Systematic Analysis of Human 5’UTR Introns Reveals Their Importance in Expression

July 26, 2009
DOI: 10.4016/12098.01
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Conference:
ISMB/ECCB 2009
Abstract:
These results suggest that 5’UTR introns enhance gene expression in a position and length dependent manner in humans. Overrepresentation of 5’UTR introns among regulatory genes suggests that they a have a disproportionate impact on gene regulation. Our results also have implications for understanding the evolution of 5’UTR introns.
Description:
Here, we describe a genome-scale computational analysis of 5’UTR introns in humans.