Clocks & Rhythms with Michael Rosbash interviewed by Sandra Kuhlman

Michael Rosbash was a post-doctoral fellow in Edinburgh and has been at Brandeis University in the Department of... » More

Michael Rosbash was a post-doctoral fellow in Edinburgh and has been at Brandeis University in the Department of Biology since 1974. He is now Professor of Biology and Director of the National Center for Behavioral Genomics. Michael Rosbash has been an HHMI Investigator since 1989 and is a member of the American Academy of Arts and Sciences and the National Academy of Sciences.

Michael Rosbash’s main interests are in gene expression and circadian rhythms, and he has worked in both fields for more than twenty-five years. The Hall and Rosbash groups cloned the Drosophila period gene and reported the first transgenic rescue of a behavioral gene; this was independently accomplished at the same time by the Young group. In collaboration with Jeff Hall, Rosbash’s group discovered that PER alters its own transcriptional cycling, an insight that is central to a contemporary view of oscillator mechanism in flies and many other organisms. More recent studies by Rosbash and colleagues have identified additional rhythm genes, addressed circadian post-transcriptional as well as transcriptional regulation, the mechanisms of light entrainment and the brain circadian network that underlies the photoperiodic regulation of locomotor activity rhythms.
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