Jennifer J. Loros is Professor of Biochemistry and of Genetics at Dartmouth Medical School. A lifelong interest in horticulture led to graduate...
Jennifer J. Loros is Professor of Biochemistry and of Genetics at Dartmouth Medical School. A lifelong interest in horticulture led to graduate work in Biology at UC Santa Cruz on circadian biological clocks and postdoctoral research at Dartmouth. As a graduate and post-doctoral student she genetically mapped and characterized the first loss-of-function allele for the frequency gene, described an early non-circadian oscillator, and found the first systematically isolated clock-controlled genes (ccg's). Dr. Loros's lab explores the genetic and molecular underpinning of circadian timing systems, the means through which fungal and mammalian clocks control gene expression and organismal behavior, molecular mechanisms of the clock's response to environmental stimuli and undertakes the isolation and identification of circadianly mutant strains. With collaborator Jay Dunlap, her lab described the first positively acting factors for a core feedback loop (the interacting PAS domain transcription factors WC-1 and WC-2), and demonstrated that the WC-1 protein was the circadian photoreceptor , while both WC proteins were required for circadian light resetting. Other work has included continuing efforts to
understand the spectrum of clock and light regulated genes, identify the molecular underpinnings of non-circadian oscillators and most recently, determine the connections between the circadian and cell cycles. She serves as Associate Editor for the journal Genetics and on the Advisory Board for the Journal of Biological Rhythms, received a NSF Creativity Award, is an AAAS Fellow and was the recipient of the Aschoff's Rule Award for her contributions to understanding circadianly regulated gene expression