

The establishment of apical–basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the underlying mechanisms, the human intestinal epithelial cell line Caco-2 was grown in a three-dimensional matrix to generate a cystlike...
Current concepts of cell migration were established in regular two-dimensional (2D) cell culture, but the roles of topography are poorly understood for cells migrating in an oriented 3D fibrillar extracellular matrix (ECM). We use a novel micropatterning technique termed microphotopatterning...
Chemoattractant signaling induces the polarization and directed movement of cells secondary to the activation of multiple effector pathways. In addition, chemotactic signals can be amplified and relayed to proximal cells via the synthesis and secretion of additional chemoattractant. The...
This animation depicts the reaction of a 3-amino acid sequence within GFP to produce a cyclic chromophore, the source of the protein's fluorescence. The starting conformation and finished cyclic chromophore are representations of actual crystal structures of GFP. Created using UCSF Chimera,...
This parody of Jay-Z's "Money Ain't a Thang" explores the wonderful world of developmental biology. Made for Human Biology 3A at Stanford University. Lyrics (shown below) by Tom McFadden, performance by Tom and Derrick Davis, cameo by Bob Siegel, and edited by Jake Wachtel. Derrick: In the...
Este video describe la hipoxia y el proceso de adaptación a las alturas.