Metabonomic profiling of the gut microbiome: Implications for human health James Kinross, Imperial College, London

Microbial-mammalian metabolic cooperation is defined as the human ‘metabonome’. Transgenomic co-metabolic... » More

Microbial-mammalian metabolic cooperation is defined as the human ‘metabonome’. Transgenomic co-metabolic interactions within the metabonome greatly increase system complexity and this presents a significant challenge for elucidating the mechanisms by which the intestinal micro biome influences the host phenotype. By measuring and mathematically modelling changes in the levels of products of metabolism found in mammalian biological fluids and tissues, metabonomics offers fresh insight into the effects of the gut microbiome on human health. This talk explores current concepts in this rapidly evolving field, and describes how metabonomics may be used as part of a systems approach for studying the intestinal microbiome. « Hide