Binding of peptides to Major Histocompatibility Complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC class I system (HLA-I) is extremely polymorphic. The number of registered HLA-I molecules has now surpassed 1500. Characterizing the specificity of each separately would be a major undertaking.
Here, we have drawn on a large database of known...
Authors: Morten Nielsen, Claus Lundegaard, Thomas Blicher, Kasper Lamberth, Mikkel Harndahl, Sune Justesen, Gustav Røder, Bjoern Peters, Alessandro Sette, Ole Lund, Søren Buus