Lung Cancer Risks raised by Genetic Variations

submitted by: mdanderson

A research team led by scientists at MD Anderson Cancer Center report that 2 specific common inherited
genetic variations are associated with increased risk of lung cancer for smokers and former smokers.
Dr. Amos talks about how the findings are a major step forward in identifying those at high risk for
non-small cell lung cancer and for understanding how smoking and genetic factors interact to cause the disease.

BIOTERRORISM: PLAGUE AS A BIOLOGICAL WEAPON

submitted by: camdic
Bioterrorism is the utilization of microorganisms or toxins in order to produce a disease and/or death in human beings, animals or plants. Different from conventional weaponry, relatively economic means are used that allow the elimination of living beings without destroying the surrounding atmosphere. The most probably method for spread of bioweapons is aerial transmission, continuing into water supplies and food. The CDC (US Centers for Disease Control and Prevention, Atlanta) has...

Interview with Computational Biologist and SciVee Cofounder Phil Bourne

linked profile(s): simont
submitted by: Phil

Prof. Simon Twigger of the Medical College of Wisconsin asked me to visit for a day in January of 2008. We started the day with this interview which Simon conducted which describes my career and interests. He kindly let us post it here. It might be of interest to anyone considering a career in computational biology as it covers one such career path which began before the field itself was established.

HUTCHINSON-GILFORD SYNDROME

submitted by: camdic

Recent studies suggest that, as in other aging syndromes, the Hutchinson-Gilford syndrome is due at to a defect in the mechanism of DNA repair. Mutations have been found in the Lamin A gene (LMNA) situated on chromosome 1.

LASSUEUR PICCARDI GRAHAM LITTLE Syndrome.

submitted by: camdic

A rare disease in which cicatricial (scarring) alopecia of the scalp is associated with widepsread keratosis pilaris particularly in the axillae and pubic area where scarring does not usually occur. The scarring in the scalp may be clinically indistinguishable from the end stage of other forms of scarring hair loss.(Abstract) Prof. Camillo O. Di Cicco,MD

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

submitted by: akshayb
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra-high–throughput sequencing to map the remodeling of individual nucleosomes throughout the yeast genome before and after a physiological perturbation that causes genome-wide transcriptional changes....
Authors: Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath r Iyer