Interview with Computational Biologist and SciVee Cofounder Phil Bourne

linked profile(s): simont
submitted by: Phil

Prof. Simon Twigger of the Medical College of Wisconsin asked me to visit for a day in January of 2008. We started the day with this interview which Simon conducted which describes my career and interests. He kindly let us post it here. It might be of interest to anyone considering a career in computational biology as it covers one such career path which began before the field itself was established.

HUTCHINSON-GILFORD SYNDROME

submitted by: camdic

Recent studies suggest that, as in other aging syndromes, the Hutchinson-Gilford syndrome is due at to a defect in the mechanism of DNA repair. Mutations have been found in the Lamin A gene (LMNA) situated on chromosome 1.

LASSUEUR PICCARDI GRAHAM LITTLE Syndrome.

submitted by: camdic

A rare disease in which cicatricial (scarring) alopecia of the scalp is associated with widepsread keratosis pilaris particularly in the axillae and pubic area where scarring does not usually occur. The scarring in the scalp may be clinically indistinguishable from the end stage of other forms of scarring hair loss.(Abstract) Prof. Camillo O. Di Cicco,MD

Dynamic Remodeling of Individual Nucleosomes Across a Eukaryotic Genome in Response to Transcriptional Perturbation

submitted by: akshayb
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra-high–throughput sequencing to map the remodeling of individual nucleosomes throughout the yeast genome before and after a physiological perturbation that causes genome-wide transcriptional changes....
Authors: Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath r Iyer

MELANOMA THERMOGRAPHY

submitted by: camdic

Thermography allows the investigator to create a 3 dimensional image based on infrared emissions from tissue. Warmer tissues show up as yellow and white, whereas darker colors represent cooler structures. Malignant tumors are metabolically active and appear yellow and white on the images.
Metastatic melanoma in left inguinal lymphonodes - metastatic melanoma in left leg -
Prof. Camillo O. Di Cicco, MD

MITOCHONDRIAL DNA LAUNOIS-BENSAUDE's LIPOMATOSIS

submitted by: camdic
Even though Brodie is said to have first described diffuse symmetrical lipomatosis with predilection for the neck already in the 1846 (Clinical Lectures on Surgery, Delivered at St. George's Hospital Philadelphia: Lea and Blanchard pub. Pp 201-201. Brodie, B.C.) still unknown is today the pathogenesis of Launois Bensaude' Lipomatosis. Klopstock et Al. are found in muscle biopsy specimens ragged and red fibers, pathologic subsarcolemmal accumulations of mitochondria, suggesting a...