Preparation of broccoli extracts for biological studies

submitted by: tkaragiannis
In this video, Katherine Ververis (Epigenomic Medicine, Baker IDI Heart and Diabetes Institute), demonstrates how to extract nutrients from the florets of broccoli. We investigate the effects of broccoli extract on the viability on human erythroleukemic K562 cells. Broccoli evolved ~2000 years ago from a wild cabbage plant in Europe and since the Roman Empire it has been considered a uniquely valuable food among Italians. The word broccoli, is derived from the Italian plural of broccolo,...

UCSD Phar201 Computational Systems Medicine

submitted by: Phil

This is a podcast and slides of a lecture given on Nov 23, 2011 in the course Phar201 (http://www.sdsc.edu/pb/edu/pharm201/) at the University of California San Diego by graduate student Roger Chang. It covers the interface between structural bioinformatics and systems biology form the viewpoint of off-target drug effects and large scale metabolic modeling.

UCSD Phar201 Protein Ligand Interactions

submitted by: Phil

This is a podcast and slides of a lecture given on Nov 02, 2011 in the course Phar201 (http://www.sdsc.edu/pb/edu/pharm201/) at the University of California San Diego by Prof. Phil Bourne. It covers some aspects of protein ligand interactions with emphasis on SMAP for determining similar ligand binding sites and the pharmacological implications.

Targeted Drug Melts Fat in Obese Monkeys

submitted by: mdanderson
An anti-obesity drug that homes in on and destroys blood vessels that support fat reduced the weight of obese rhesus monkeys by 11 percent in one month. It also trimmed their waistlines by eradicating 27 percent of their abdominal fat. Obesity raises a person's risk for developing breast, ovarian, prostate, colon and other cancers and also hinders treatment for cancer patients. Scientists at The University of Texas MD Anderson Cancer Center who developed the drug discuss results of the...

Dietary Ellagic Acid Attenuates Oxidized LDL Uptake and Stimulates Cholesterol Efflux in Murine Macrophages

submitted by: shpark
Foam cell formation is the hallmark of early atherosclerosis. Lipid uptake by scavenger receptors (SR) in macrophages initiates chronic proinflammatory cascades linked to atherosclerosis. It has been reported that the upregulation of cholesterol efflux may be protective in the development of atherosclerosis. Ellagic acid, a polyphenolic compound mostly found in berries, walnuts, and pomegranates, possesses antioxidative, growth-inhibiting and apoptosis-promoting activities in cancer...
Authors: Young-Hee Kang, Min-Kyung Kang, Ju-Hyun Gong, Seon-Young Han, Eun-Sook Lee, Jung-Lye Kim, Sin-Hye Park

Cured from Crohn's disease with Auto-hemotherapy

submitted by: Auto-hemotherapy
Cured from Crohn's disease with Auto-hemotherapy My name is Jose Luiz Dutra, I am now 77 years old and live in the city of Salvador, state of Bahia, Brazil. Crohn's disease is considered incurable and is characterised by a bowel ulcer, great discomfort of the intestinal flow, weight loss and negative psychological effects. For over 10 years, I was suffering from this disease, taking traditional medicines, such as azulfim, mesacol, etc, without any improvement and having...