BIOTERRORISM: PLAGUE AS A BIOLOGICAL WEAPON

submitted by: camdic
Bioterrorism is the utilization of microorganisms or toxins in order to produce a disease and/or death in human beings, animals or plants. Different from conventional weaponry, relatively economic means are used that allow the elimination of living beings without destroying the surrounding atmosphere. The most probably method for spread of bioweapons is aerial transmission, continuing into water supplies and food. The CDC (US Centers for Disease Control and Prevention, Atlanta) has...

Cheminformatics in Open Notebook Science

submitted by: jcbradley

Jean-Claude Bradley guest lectures on Rajarshi Guha's cheminformatics course at Indiana University. After an introduction to Open Notebook Science and the synthesis of anti-malarial compounds, topics include SMILES, InChIs, InChIKeys, CMLRSS, JCAMP-DX, JSpecView, ExcelVBA, blogs, wikis and Second Life.

HUTCHINSON-GILFORD SYNDROME

submitted by: camdic

Recent studies suggest that, as in other aging syndromes, the Hutchinson-Gilford syndrome is due at to a defect in the mechanism of DNA repair. Mutations have been found in the Lamin A gene (LMNA) situated on chromosome 1.

LASSUEUR PICCARDI GRAHAM LITTLE Syndrome.

submitted by: camdic

A rare disease in which cicatricial (scarring) alopecia of the scalp is associated with widepsread keratosis pilaris particularly in the axillae and pubic area where scarring does not usually occur. The scarring in the scalp may be clinically indistinguishable from the end stage of other forms of scarring hair loss.(Abstract) Prof. Camillo O. Di Cicco,MD

MELANOMA THERMOGRAPHY

submitted by: camdic

Thermography allows the investigator to create a 3 dimensional image based on infrared emissions from tissue. Warmer tissues show up as yellow and white, whereas darker colors represent cooler structures. Malignant tumors are metabolically active and appear yellow and white on the images.
Metastatic melanoma in left inguinal lymphonodes - metastatic melanoma in left leg -
Prof. Camillo O. Di Cicco, MD

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

submitted by: mmcguckin
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis....
Authors: Heazlewood CK, Cook MC, Eri R, Price G, Tauro S, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall, RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin THJ, Goodnow CC, McGuckin MA