Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

submitted by: mmcguckin
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis....
Authors: Heazlewood CK, Cook MC, Eri R, Price G, Tauro S, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall, RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin THJ, Goodnow CC, McGuckin MA

MITOCHONDRIAL DNA LAUNOIS-BENSAUDE's LIPOMATOSIS

submitted by: camdic
Even though Brodie is said to have first described diffuse symmetrical lipomatosis with predilection for the neck already in the 1846 (Clinical Lectures on Surgery, Delivered at St. George's Hospital Philadelphia: Lea and Blanchard pub. Pp 201-201. Brodie, B.C.) still unknown is today the pathogenesis of Launois Bensaude' Lipomatosis. Klopstock et Al. are found in muscle biopsy specimens ragged and red fibers, pathologic subsarcolemmal accumulations of mitochondria, suggesting a...

Microbial Observatory - Partners Video Magazine

submitted by: csrees
Researcher Jo Handelsman runs microbial observatories in Wisconsin and Alaska and studies underground microbes detrimental to healthy soil. Microbial Observatory is a segment from CSREES' Partners Video Magazine's 19th episode, The Soil Explorers. To view the entire episode, go to http://www.csrees.usda.gov/newsroom/partners/soil_explorers.html .

HIV Dermatology

submitted by: camdic

Objective: Study of cutaneous displays found during AIDS, spy of early diagnosis of disease.

3D-Darstellung des terminalen Bronchialbaums

submitted by: habi

Vortrag über meine Arbeit der letzten Monate am Tag der Anatomie 2008
Talk about my recent work at the "Tag der Anatomie 2008", an inhouse talk-session.