Control and Regulation of Stem Cells with Ron McKay Interviewed by Richard Sever

Ron McKay received a B.Sc. in 1971 and a Ph.D. in 1974 from University of Edinburgh, where he studied under the tutelage of Edwin Southern examining DNA organization and chromosome structure. He received postdoctoral training at University of Oxford working with Walter Bodmer examining restriction-fragment-length polymorphism (RFLPs). In 1978, he became a senior staff investigator at Cold Spring Harbor Laboratory concentrating on two areas: the interaction of SV40 T antigen with the specific...

Control and Regulation of Stem Cells with Arturo Alvarez-Buylla Interviewed by Jane Alfred

Arturo Alvarez-Buylla is the Heather and Melanie Muss Endowed Chair in the Department of Neurological Surgery and Professor of the Institute for Regeneration Medicine, University of California, San Francisco (UCSF). He received his undergraduate degree from National Autonomous University of Mexico (UNAM). In 1988 he obtained his PhD from Rockefeller University and after a brief postdoctoral fellowship, becomes Assistant Professor and then Associate Processor-Head of Laboratory at this same...

Control and Regulation of Stem Cells with Rudolf Jaenisch Interviewed by Richard Sever

Rudolf Jaenisch received his M.D. in Munich in 1967. After postdoctoral work at Princeton and five years as a Research Professor at the Salk Institute, he became Head of the Department of Tumor Virology at the Heinrich Pette Institute for Experimental Virology and Immunology. Since 1984 he has been a Founding Member of the Whitehead Institute and Professor of Biology at M.I.T. and in 2005 he established the Human Stem Cell Facility at the Whitehead. Dr. Jaenisch is a pioneer in making...

Setting the Stage: Mobilizing the Metagenomics Community

submitted by: dougramsey

About 250 leaders in the emerging science of metagenomics converged at the UC San Diego division of the California Institute for Telecommunications and Information Technology (Calit2) earlier this month for the third Annual International Conference on Metagenomics. The conference was a week-long opportunity to share data and discuss the latest research, explore how advances in computing and sequencing technologies might be of benefit, and build or strengthen collaborations in the field.

Towards Transparency of Computational Analyses: A Central SOP Repository

submitted by: dougramsey
The methodologies used to generate genome and metagenome annotations are diverse and vary between groups and laboratories. Descriptions of the annotation process are helpful in interpreting genome annotation data. Some groups have produced Standard Operating Procedures (SOPs) that describe the annotation process, but standards are lacking for structure and content of these descriptions. A general structure for SOP documents that are relevant to genome annotation, metagenomics, environmental...

Challenges in Ecological Metagenomics

submitted by: dougramsey
Since the first metagenomics study was published 17 years ago, the ability to make ecological inferences has been limited by sequencing throughput and the ability to analyze the data. Yet, if the potential of metagenomics to help us decipher the structure and function of microbial ecosystems is to be realized, it is essential that our bioinformatics tools motivate our sequencing efforts. This is analogous to the bioinformatics advances that were made to accelerating the sequencing of the...