Genome-wide association study of chronic periodontitis in a general German population

submitted by: ateumer
Aim: To identify loci associated with chronic periodontitis through a genome wide association study (GWAS). Materials and Methods: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n=3365 and SHIP-TREND n=667) with the different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genomes based...
Authors: A Teumer, B Holtfreter, U Völker, A Petersmann, M Nauck, R Biffar, H Völzke, HK Kroemer, P Meisel, G Homuth, T Kocher

biosights: September 2, 2013 - Shrinking microtubules pull the centrosome into place

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that connects the two cells. Yi et al. reveal that centrosome repositioning is a biphasic process driven by the dynein-dependent capture and depolymerization of microtubules. This biosights episode presents the paper by Yi et al. from the September 2, 2013, issue of The Journal of Cell Biology and includes an interview with senior author John Hammer (NHLBI, Bethesda, MD). Produced...

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

David Bhella: The Peter Wildy Award Talk (MWV75)

submitted by: MicrobeWorld

David Bhella, Ph.D., MRC Centre for Virus Research, accepts the Peter Wildy Prize for Microbiology Education, awarded annually by the Society for General Microbiology for an outstanding contribution to microbiology education. Recorded live March 25, 2013 in Manchester, UK.

biosights: August 5, 2013 - Epithelia restored by healing waves

submitted by: JCB
Epithelial cells around the edge of a wound assemble an actomyosin cable that constricts to draw the wound closed, but the events that precede cable formation are largely unknown. Antunes et al. reveal that wounding induces a wave of actomyosin assembly and cell constriction that flows toward the wound edge to promote cable assembly and tissue repair. This biosights episode presents the paper by Antunes et al. from the July 22, 2013, issue of The Journal of Cell Biology and includes an...

Fusion of Arts and Sciences: The Third Culture?

submitted by: UP Los Baños

Documentation of the lecture on "Fusion of Arts and Sciences: The Third Culture?" by Dr. Asuncion K. Raymundo, Professor Emeritus, during the "Celebrating UPLB's Great Minds Lecture Series" on July 26, 2013 at the UPLB Operations Room, UPLB, College, Laguna