20131022 - Protein Prediction 2 - Burkhard Rost - Individual Health

submitted by: rostlab

Date: 20131022

Course: Protein Prediction 2

Title: Individual Health

Speaker: Burkhard Rost

Audience: Computer Science students

20131022 - Protein Prediction 2 - Burkhard Rost - Individual Health

submitted by: rostlab

Date: 20131022

Course: Protein Prediction 2

Title: Individual Health

Speaker: Burkhard Rost

Audience: Computational Biology students

biosights: October 28, 2013 - A framework for understanding muscle microtubules

submitted by: JCB
The microtubules of skeletal muscle fibers are arranged into an orthogonal grid, but how this network is formed is unknown. Oddoux et al. reveal that the network is built by dynamic microtubules nucleated from Golgi elements. This biosights episode presents the paper by Oddoux et al. from the October 28, 2013, issue of The Journal of Cell Biology and includes an interview with senior author Evelyn Ralston (NIH, Bethesda, MD). Produced by Caitlin Sedwick and Ben Short. See the associated...

biosights: September 30, 2013 - The nodal network

submitted by: JCB
In addition to specialized actin structures such as lamellipodia and stress fibers, cells are thought to contain a contractile actomyosin matrix that maintains cell shape. Luo et al. describe the organization and dynamics of an actomyosin network that may fulfill this function. This network is formed by actin nodes that contain the formin DAAM1 and the crosslinker filamin A, and that are connected to each other by myosin II. This biosights episode presents the paper by Luo et al. from the...

Genome-wide association study of chronic periodontitis in a general German population

submitted by: ateumer
Aim: To identify loci associated with chronic periodontitis through a genome wide association study (GWAS). Materials and Methods: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n=3365 and SHIP-TREND n=667) with the different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genomes based...
Authors: A Teumer, B Holtfreter, U Völker, A Petersmann, M Nauck, R Biffar, H Völzke, HK Kroemer, P Meisel, G Homuth, T Kocher

biosights: September 2, 2013 - Shrinking microtubules pull the centrosome into place

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that connects the two cells. Yi et al. reveal that centrosome repositioning is a biphasic process driven by the dynein-dependent capture and depolymerization of microtubules. This biosights episode presents the paper by Yi et al. from the September 2, 2013, issue of The Journal of Cell Biology and includes an interview with senior author John Hammer (NHLBI, Bethesda, MD). Produced...