biosights: July 7, 2014 - The fluid dynamics of collective cell migration

submitted by: JCB
During development and tumor metastasis, cells prepare to migrate by undergoing an epithelial-to-mesenchymal transition that loosens their connections to neighboring cells. But some cell types then migrate en masse to their final destinations, indicating that their intercellular adhesions aren't disrupted completely. Kuriyama et al. reveal that the phospholipid lysophosphatidic acid promotes the collective migration of Xenopus neural crest cells by downregulating the surface expression of...

PharmGenEd™ Principles and Concepts of Pharmacogenomics

submitted by: KuoOffice

The presentation is divided into several sections as outlined by the powerpoint slide. In this module we will include the basic concepts of pharmacogenomics, ethical, legal, social issues, and a brief introduction of the PharmGenEd program.

biosights: June 9, 2014 - Rab18 tilts the balance of ER structure

submitted by: JCB
The endoplasmic reticulum consists of peripheral tubular networks connected to sheet-like domains surrounding the nucleus. Gerondopoulos et al. reveal that the Rab3GAP complex, which is mutated in the neurodevelopmental disorder Warburg Micro Syndrome, is a guanine nucleotide exchange factor that activates the small GTPase Rab18 (also mutated in Warburg Micro Syndrome) to control the balance between ER tubules and sheets. This biosights episode presents the paper by Gerondopoulos et al. from...

I-CAMP 2014

submitted by: icamvid

I-CAMP 2014

biosights: May 12, 2014 - Phosphoinositides get cells in shape

submitted by: JCB
Early Drosophila embryos undergo 13 rounds of rapid nuclear division before enclosing each nucleus into an individual, membrane-bound cell. Reversi et al. describe how the phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 control the resulting cell shapes by coordinating actomyosin contractility with plasma membrane expansion. This biosights episode presents the paper by Reversi et al. from the May 12, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Stefano...

Genetic engineering and the production of molecules

submitted by: nsf

Theoretical biophysicist William Bialek discusses genetic engineering and how the placement of instructions for a gene alters an organism.