Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how cells move through three-dimensional environments is less well understood. Petrie et al. reveal that, depending on the strength of intracellular RhoA signaling and on the elastic properties of the extracellular matrix, fibroblasts can migrate through 3D environments using either lamellipodia or blunt, cylindrical protrusions called lobopodia. This biosights episode presents the...

Steven Benner from the Foundation for Applied Molecular Evolution delivering the closing keynote at the 7th Annual Genomics of Energy & Environment Meeting on March 22, 2012 in Walnut Creek, Calif.

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating fibroblasts, but their exact function in persistent motility remains unclear. Welf et al. reveal that PI3K signaling helps reorient migrating fibroblasts by stabilizing branched protrusions at the leading edge, allowing the cell to pivot and move in a different direction. This biosights episode presents the paper by Welf et al. from the April 2, 2012, issue of The Journal of Cell...

This tutorial describes how to discover potentially new targets that may bind your compounds of interest in BindingDB. This unique capability is based on the principle that similar compounds tend to bind the same proteins.

A quick intro to BioProject. For more information see http://blog.openhelix.eu/?p=11931

Adam Arkin from Berkeley Lab on the DOE Systems Biology Knowledgebase (Kbase) at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, Calif.