Protein Secretion and Vesicle Traffic by Randy Schekman - Part 1: Genetic Dissection of the Secretory Pathway (36:35)

submitted by: video_collector
Protein secretion is executed by a cellular pathway involving the delivery of membrane and soluble secretory proteins in vesicles that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and sorted in the Golgi apparatus. Vesicles fuse with the plasma membrane resulting in the discharge of soluble molecules to the cell exterior and integration of vesicle membrane proteins and lipids in the cell surface. Baker's yeast cells grow by vesicle fusion and secretion at...


submitted by: camdic
Incontinentia pigmenti, is a rare genodermatosis, also called Bloch-Sulzberger syndrome or Bloch-Siemens, that shows early at birth or in the neonatal period. In its classical form, the cutaneous symptomatology develops through three steps. 1st step, with evidence of injuries, of erythematic-vescicular-blistered kind and one wave after another, linearly positioned and involving upper body and limbs;haematic hypereosinophilia is also present. 2nd step, that pops up between the second and...

Stem Cells: Biology and Promise for Regenerative Medicine by Elaine Fuchs, Jan. 2007 - Part 1: Introduction to Stem Cells and Ethical Issues (35:11)

submitted by: video_collector
During embryogenesis, a single fertilized oocyte gives rise to a multicellular organism whose cells and tissues have adopted differentiated characteristics or fates to perform the specified functions of each organ of the body. As embryos develop, cells that have acquired their particular fate proliferate, enabling tissues and organs to grow. Even after an animal is fully grown, however, many tissues and organs maintain a process known as homeostasis, where as cells die, either by natural...

Genes and Cells that Determine the Lifespan of C. elegans - Part 1: An Evolutionarily-Conserved Regulatory System for Aging (42:46)

submitted by: video_collector
Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other signals. In the nematode C. elegans, in which many key discoveries about aging were first made, the aging process is subject to regulation by food intake, sensory perception, and signals from the reproductive system. Changing genes and cells that affect aging can lengthen lifespan by six fold, and...

Polyketide Biosynthesis: The Erythromycin Example - Part 1: Overview of Polyketides and Polyketide Biosynthesis (34:10)

submitted by: video_collector

In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented.

For further informaton see:

Rudolph Jaenisch Interview

submitted by: rsever

Stem cell expert Rudolph Jaenisch is interviewed by Richard Sever of Cold Spring Harbor Laboratory following his keynote lecture at the 2008 Cold Spring Harbor Symposium on Quantitative Biology