Bioengineering Synovial Fluid with Modulated Hyaluronan Molecular Weight and Function

submitted by: bjlao
This project seeks to gain a better understanding of (1) how cytokines regulate the molecular weight (MW) of the synovial fluid (SF) lubricant molecule hyaluronan (HA), and (2) the relationship between HA MW and lubricating function, to aid in bioengineering functional SF in bioreactors. The regulatory effects of SF cytokines IL-1?, IL-17, IL-32, TGF-?1, and TNF-? on HA MW will be assessed by image-processing analysis of a novel separation and staining method, and the lubricating function...

Statistical-based Control Wrapper for Automated Neuroimaging Data Processing

submitted by: jiwu

The field of functional neuroimaging heavily utilizes numerical data processing, but a lack of uniformity and standarization of subject data and statistical testings heavily cripples working efficiency. This project plans to produce a statistical-based control wrapper that attempts the automated implementation of standarization given an unknown workspace.

Advances to the Biochemical, Genetic and Genomic (BiGG) Database

submitted by: jypark
The BiGG database is a widely used resource for sharing genome-scale metabolic reconstructions. BiGG integrates several published genome-scale metabolic networks into one resource with standard nomenclature which allows components to be compared across different species. Furthermore, BiGG contains links to several publicly available databases where additional information can be found and integrated. In addition, BiGG contains a customized export tool that enables the generation of SBML...

Digital Archaeology in the Southern Levant

submitted by: charwang

In an effort to update and modernize the field of archaeology, site architectural plans, stratigraphic profiles, and ceramic plates will be digitalized and vectorized to be presented in a queryable online database. The creation of a queryable database, to replace print media, would allow for complex statistical and analytical computations between and within archaeological sites.

L-DOPA Is an Endogenous Ligand for OA1

submitted by: medtv
Albinism is a genetic defect characterized by a loss of pigmentation. The neurosensory retina, which is not pigmented, exhibits pathologic changes secondary to the loss of pigmentation in the retina pigment epithelium (RPE). How the loss of pigmentation in the RPE causes developmental defects in the adjacent neurosensory retina has not been determined, but offers a unique opportunity to investigate the interactions between these two important tissues. One of the genes that causes albinism...
Authors: Lopez Vm, Decatur Cl, Stamer Wd, Lynch Rm, Mckay Bs

Quantifying Random Genomic Mutations in CLL

submitted by: arivken

Rolling circle amplification is used to create nanoparticles which consist of long single stranded DNA of an immunogenic sequence, specifically, a CpG sequence. The ssDNA coils into a spherical nanoparticle structure which will stimulate the patients own immune system to rid itself of cancer.