New York-SGX Research Center for Structural Genomics

submitted by: dougramsey

Brief Report on Collaboration with Gerlt/Raushel P01 Consortium

Roger Tsien Gives Nobel Lecture at UC San Diego

submitted by: ucsandiego

UC San Diego Nobel Laureate Roger Tsien Gives His Nobel Lecture Feb. 18 at the Price Center Theater.

Reconstruction of Alternative Splice Variants and Associated Abundances from Short Sequence Reads (CSHL Genome Informatics Conference 2008)

submitted by: micha
The FLUX CAPACITOR : next generation sequencing technologies provide an unprecedented capacity for surveying the nucleic acid content of cells. This profound sequencing depth may allow in particular for exhaustively sequencing through the large dyanimc range of RNA abundances in the cell, overcoming limitations imposed by current (random) clone selection approaches. However, the very short reads produced by the most cost-effective such technologies make the reconstruction of complete RNA...

Protein Modeling Practice: Zinc Fingers

submitted by: zardecki

Demonstration of how to build a 3D toober model of a zinc finger using the RCSB PDB website and Jmol

Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

Apparency and Actuality

submitted by: hsrikm
Apparency and actuality are discussed with respect to science, genetics, evolution, cognition and perception. Rules for a (sub)set of actual/allowable sets of entities and objects from a total set that is based on differences and contrasts extracted from perceptual experience of the world elucidate tenable combinations/recombinations from a total of the transparent(history/past dependant) and the apparent as they can be construed to comprise the actual/real faces of perception. The elements...