Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

Apparency and Actuality

submitted by: hsrikm
Apparency and actuality are discussed with respect to science, genetics, evolution, cognition and perception. Rules for a (sub)set of actual/allowable sets of entities and objects from a total set that is based on differences and contrasts extracted from perceptual experience of the world elucidate tenable combinations/recombinations from a total of the transparent(history/past dependant) and the apparent as they can be construed to comprise the actual/real faces of perception. The elements...

The Laws of Physics, Paradox, and Orderly Conduct in the Randomness Zone

submitted by: hsrikm
A conceptualization of the universe as a nonrandom entity in light of a universal particular established from certain descriptive properties of space, but randomly behaving at all perspectives, is proposed as a outline for the interpretation of nature. This view enables the construction of a natural ethic in which many of the orderly conducts of science become exposed as inductive, falling short of being logically sound and valid, result in false interpretations and a permissiveness with...

Developmental Biology of a Simple Organism by Richard Losick, April 2008 - Part 1: How Bacillus Subtilis Makes a Spore (28:57)

submitted by: video_collector

How do simple cells differentiate, assemble into communities, and cope with change? Losick's seminar addresses these questions in the spore-forming bacterium Bacillus subtilis. Part I is an overview of how B. subtilis makes a spore.

For further information see: http://www.ascb.org/ibioseminars/Losick/Losick1.cfm

Cytoskeletal Motor Proteins by Ron Vale, July 2007 - Part 1: Introduction to Motor Proteins (43:13)

submitted by: video_collector
Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In the first part of this lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The main focus of this lecture is on how motor proteins work. How does a nanoscale protein convert energy from ATP hydrolysis into unidirectional motion and force production? What tools...