Modeling Fragmentation Patterns of ECD/ETD Mass Spectrometers

submitted by: patel.anandd

Mass spectrometers are sophisticated instruments that detect the mass of ionized molecules, which is useful in the field of chemistry and most recently proteomics. Newer spectrometers ionize and fragment molecules with different specificity and resolution, which requires understanding and applying these newer fragmentation patterns to current peptide sequencing algorithms like InsPect.

Soft mechanical actuators: Applications in artificial implants, biomimicking devices, and stem cell culture.

submitted by: hanliang

Our project will be focused on the development of a multifunctional oscillating hydrogel device that undergoes reversible, time dependent and sinusoidal volume/mechanical changes in response to temperature perturbations. These oscillating hydrogels will then be employed inregulating musculoskeletal differentiation of stem cells in the context of regenerative medicine.

Bioengineering Synovial Fluid with Modulated Hyaluronan Molecular Weight and Function

submitted by: bjlao
This project seeks to gain a better understanding of (1) how cytokines regulate the molecular weight (MW) of the synovial fluid (SF) lubricant molecule hyaluronan (HA), and (2) the relationship between HA MW and lubricating function, to aid in bioengineering functional SF in bioreactors. The regulatory effects of SF cytokines IL-1?, IL-17, IL-32, TGF-?1, and TNF-? on HA MW will be assessed by image-processing analysis of a novel separation and staining method, and the lubricating function...

Statistical-based Control Wrapper for Automated Neuroimaging Data Processing

submitted by: jiwu

The field of functional neuroimaging heavily utilizes numerical data processing, but a lack of uniformity and standarization of subject data and statistical testings heavily cripples working efficiency. This project plans to produce a statistical-based control wrapper that attempts the automated implementation of standarization given an unknown workspace.

Advances to the Biochemical, Genetic and Genomic (BiGG) Database

submitted by: jypark
The BiGG database is a widely used resource for sharing genome-scale metabolic reconstructions. BiGG integrates several published genome-scale metabolic networks into one resource with standard nomenclature which allows components to be compared across different species. Furthermore, BiGG contains links to several publicly available databases where additional information can be found and integrated. In addition, BiGG contains a customized export tool that enables the generation of SBML...

Digital Archaeology in the Southern Levant

submitted by: charwang

In an effort to update and modernize the field of archaeology, site architectural plans, stratigraphic profiles, and ceramic plates will be digitalized and vectorized to be presented in a queryable online database. The creation of a queryable database, to replace print media, would allow for complex statistical and analytical computations between and within archaeological sites.