Genes and Cells that Determine the Lifespan of C. elegans - Part 1: An Evolutionarily-Conserved Regulatory System for Aging (42:46)

submitted by: video_collector
Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other signals. In the nematode C. elegans, in which many key discoveries about aging were first made, the aging process is subject to regulation by food intake, sensory perception, and signals from the reproductive system. Changing genes and cells that affect aging can lengthen lifespan by six fold, and...

Polyketide Biosynthesis: The Erythromycin Example - Part 1: Overview of Polyketides and Polyketide Biosynthesis (34:10)

submitted by: video_collector

In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented.

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Rudolph Jaenisch Interview

submitted by: rsever

Stem cell expert Rudolph Jaenisch is interviewed by Richard Sever of Cold Spring Harbor Laboratory following his keynote lecture at the 2008 Cold Spring Harbor Symposium on Quantitative Biology

Effects of Navy Sonar

submitted by: D Andrade

shows pictures of whales

Design and Testing of Protein Combinatorial Libraries - Part 1: Introduction to Protein Design by Computation (31:09)

submitted by: video_collector
In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high...

What Genomes Can Tell Us About the Past by Sydney Brenner - Part 1: (39:06)

submitted by: video_collector
By looking at the light from distant galaxies and having well-established calibration methods, astrophysics can make hypotheses about the history of our universe. Do we have similar "rulers" in biology that could allow us to reconstruct the remote past and the evolution of species on this planet? The answer is likely "yes" and the clues are undoubtedly contained in the many whole genome sequences that are now available for inspection. However, it is critical to evaluate the assumptions that...