biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical constriction

submitted by: JCB
Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains of a group of epithelial cells to drive their invagination into a ventral furrow. Vasquez et al. reveal that Rho kinase and myosin phosphatase dynamically regulate these myosin pulses and that the stepwise constriction resulting from this helps maintain tissue integrity during epithelial invagination. This biosights episode presents the paper by Vasquez et al. from the August...

Eddy Rubin at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI
Eddy Rubin, DOE JGI Director, at the 9th Annual Genomics of Energy & Environment Meeting on March 19, 2014 in Walnut Creek, Calif. The talk is related to a study published in the journal Science - details at http://jgi.doe.gov/glimpse-natures-looking-glass-to-find-the-genetic-cod... .

Rytas Vilgalys at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI

Rytas Vilgalys, Duke University, speaking at the 9th Annual Genomics of Energy & Environment Meeting on March 19, 2014 in Walnut Creek, Calif.

biosights: July 7, 2014 - The fluid dynamics of collective cell migration

submitted by: JCB
During development and tumor metastasis, cells prepare to migrate by undergoing an epithelial-to-mesenchymal transition that loosens their connections to neighboring cells. But some cell types then migrate en masse to their final destinations, indicating that their intercellular adhesions aren't disrupted completely. Kuriyama et al. reveal that the phospholipid lysophosphatidic acid promotes the collective migration of Xenopus neural crest cells by downregulating the surface expression of...

PharmGenEd™ Principles and Concepts of Pharmacogenomics

submitted by: KuoOffice

The presentation is divided into several sections as outlined by the powerpoint slide. In this module we will include the basic concepts of pharmacogenomics, ethical, legal, social issues, and a brief introduction of the PharmGenEd program.

biosights: June 9, 2014 - Rab18 tilts the balance of ER structure

submitted by: JCB
The endoplasmic reticulum consists of peripheral tubular networks connected to sheet-like domains surrounding the nucleus. Gerondopoulos et al. reveal that the Rab3GAP complex, which is mutated in the neurodevelopmental disorder Warburg Micro Syndrome, is a guanine nucleotide exchange factor that activates the small GTPase Rab18 (also mutated in Warburg Micro Syndrome) to control the balance between ER tubules and sheets. This biosights episode presents the paper by Gerondopoulos et al. from...