Background The ability to predict antibody binding sites (aka antigenic determinants or B-cell epitopes) for a given protein is a precursor to new vaccine design and diagnostics. Among the various methods of B-cell epitope identification X-ray crystallography is one of the most reliable methods. Using these experimental data computational methods exist for B-cell epitope prediction. As the number of structures of antibody-protein complexes grows, further interest in prediction...

Background The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. Results Our analysis of several vertebrate GRs and MRs in the context of 3D structures of human GR and MR indicates that with the exception of skate GR, a cartilaginous fish, there is a...

Objective: Study of cutaneous displays found during AIDS, spy of early diagnosis of disease.

Andy McCammon discusses "Computational Science and Drug Discovery" at The Minority-Serving Institutions Cyberinfrastructure Institute (MSICI2) Preliminary Program at the San Diego Supercomputing Center, University of California San Diego La Jolla, California | June 26-29, 2006

My talk at the "Tag der Anatomie 2007"

Lecture on gene expression studies of cancer and gene transcription signatures. Part of the Computer-Aided Discovery Methods course taught at Baylor College of Medicine.