INCONTINENTIA PIGMENTI

submitted by: camdic
Incontinentia pigmenti, is a rare genodermatosis, also called Bloch-Sulzberger syndrome or Bloch-Siemens, that shows early at birth or in the neonatal period. In its classical form, the cutaneous symptomatology develops through three steps. 1st step, with evidence of injuries, of erythematic-vescicular-blistered kind and one wave after another, linearly positioned and involving upper body and limbs;haematic hypereosinophilia is also present. 2nd step, that pops up between the second and...

Quality guided wide field x-ray tomographic imaging

submitted by: habi

How to increase the FOV of tomographic imaging

Conus Peptides by Baldomero "Toto" Olivera, May 2006 - Part 1: Historical Background: Discovery of a Drug (23:40)

submitted by: video_collector
Although snails are not the first animals that come to mind when venoms are mentioned, there are in fact a large number (~10,000 species) of different venomous predatory snails. The most intensively studied of these are the cone snails (Conus), which have a large number of peptide neurotoxins present in their venoms. Some cone snail venoms are lethal to man; one species causes a 70% fatality rate. How these venoms have been used to understand the nervous system, and how the characterization...

Adhesion, Signaling and Cancer by Mary C. Beckerle, July 2007 - Part 1: Understanding Cancer From Its Beginnings (36:04)

submitted by: video_collector
Cell-substratum adhesion is mediated by integrins, a family of transmembrane, heterodimeric, extracellular matrix receptors that are concentrated at focal adhesions. Integin engagement influences a variety of signaling pathways and regulates cell behaviors including motility, proliferation, and survival. Disturbance of normal integrin function is associated with a variety of pathologic conditions including cancer. In the first segment of my seminar, I provide a broad overview of the cancer...

Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapies by Brian Druker, March 2007 - Part 1: Chronic Myeloid Leukemia (CML) and Imatinib (33:54)

submitted by: video_collector
Imatinib (Gleevec) has become a paradigm for targeted cancer therapies. The first part of this lecture will describe the clinical features and the molecular pathogenesis of the disease for which imatinib was developed, chronic myeloid leukemia (CML). This overview will trace the history of the identification of the target of imatinib, BCR-ABL. The preclinical development of the BCR-ABL kinase inhibitor, imatinib and highly successful clinical trials of this agent for patients with CML will...

Stem Cells: Biology and Promise for Regenerative Medicine by Elaine Fuchs, Jan. 2007 - Part 1: Introduction to Stem Cells and Ethical Issues (35:11)

submitted by: video_collector
During embryogenesis, a single fertilized oocyte gives rise to a multicellular organism whose cells and tissues have adopted differentiated characteristics or fates to perform the specified functions of each organ of the body. As embryos develop, cells that have acquired their particular fate proliferate, enabling tissues and organs to grow. Even after an animal is fully grown, however, many tissues and organs maintain a process known as homeostasis, where as cells die, either by natural...