Role of the Neural Crest in Vertebrate Development and Evolution by Nicole Le Douarin, March 2008 - Part 1: The Quail Chick Marker System and Its Use to Study the Ontogeny of the Neural Crest (24:45)

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The neural crest (NC) is a transitory structure of the Vertebrate embryo. It forms when the neural tube closes through the epithelio- mesenchymal transition of the cells in the joining neural folds. Its constitutive cells are endowed of migratory capacities and are highly pluripotent. NC cells migrate in the developing embryo along definite pathways, at precise periods of time during embryogenesis and settle in elected sites in the body where they develop into a large of cell types. The...

The Problem of Regeneration - Part 1: A Brief (Natural) History of Regeneration (32:38)

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Regeneration has fascinated philosophers and scientists since the beginning of history. The wide but uneven distribution of regenerative capacities among multicellular organisms is puzzling, and the permissive/inhibitory mechanisms regulating this attribute in animals remain a mystery. In the first part of this lecture, I will provide a general history of regeneration research from ancient Greece to the beginning of the 20th century. Key concepts will be introduced in their appropriate...

Tuberculosis: A Persistent Threat to Global Health - Part 1: Tuberculosis: The Once and Future Plague (27:33)

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Human population growth and urbanization have accelerated dramatically in recent centuries, providing unprecedented opportunities for microbes that use our bodies as vehicles for their own propagation and transmission. These conditions have led to the emergence of virulent new pathogens and the increased prevalence of "classic" scourges, such as Mycobacterium tuberculosis. This tenacious microbe is transmitted via infectious aerosols produced by individuals with pulmonary tuberculosis....

The Dynamic Bacterial Cell: Part 1: Dynamics of Bacterial Chromosome Organization, Segregation, and Cytokinesis (34:32)

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Most bacterial cells have their genes arranged in a single circle of DNA. The circle of DNA plus some attached proteins is referred to as the bacterial chromosome. Up until quite recently, it was thought that the chromosome in the tiny bacteria cell resembled a tangled ball of yarn. It is now known that multiple factors cooperate to condense DNA into a highly dynamic assembly of supercoiled loops. Although there is variability in the lower levels of chromosome structure, the global...

Malaria presented by Joseph DeRisi, June 2006 - Part 1: Malaria: Background & Overview (21:19)

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This brief set of three lectures gives a very general overview of malaria, the disease and Plasmodium falciparum, the causative agent of the most deadly form. Basic research as well as drug development efforts will also be covered in parts two and three of this series. For further information see: http://www.ascb.org/ibioseminars/DeRisi/DeRisi1.cfm

Danger from the Wild: HIV, Can We Conquer It? by David Baltimore, Feb. 2007 - Part 1: Introduction to Viruses: HIV and Non-equilibrium Viruses (34:06)

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In this set of lectures, I describe the threat facing the world from the human immunodeficiency virus (HIV) and a bold proposal on how we might meet the challenge of eliminating this disease by engineering the immune system. In part 1, I provide a broad introduction to viruses, describing their basic properties and my own history of studying the replication RNA viruses which led to the discovery of reverse transcriptase. I also illustrate the distinguishing features of equilibrium viruses...