Grape Powder Supplementation Prevents Oxidative Stress–Induced Anxiety-Like Behavior, Memory Impairment, and High Blood Pressure in Rats

submitted by: ssalim
We examined whether or not grape powder treatment ameliorates oxidative stress–induced anxiety-like behavior, memory impairment, and hypertension in rats. Oxidative stress in Sprague-Dawley rats was produced by using L-buthionine- (S,R)-sulfoximine (BSO). Four groups of rats were used: 1) control (C; injected with vehicle and provided with tap water), 2) grape powder–treated (GP; injected with vehicle and provided for 3 wk with 15 g/L grape powder dissolved in tap water), 3)...
Authors: Farida Allam, An Dao, Gaurav Chugh, Ritu Bohat, Faizan Jafri, Gaurav Patki, Christopher Mowrey, Mohammad Asghar, Karim Alkadhi, Samina Salim

Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine

submitted by: Michelle Murphy
ABSTRACT Background: Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy. Objective: The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy. Design: Fasting plasma folate, cobalamin, free choline, betaine, dimethylglycine, and total homocysteine (tHcy) were measured longitudinally at ,12, 15, 24–27, and 34 gestational weeks (GW); at labor (nonfasting);...
Authors: Silvia Fernandez-Roig, Michelle M Murphy

Functional reconstitution of NKT cells in HIV-1 infected individuals

submitted by: dzhoumda
A reduction in the generation of lung-homing TB-specific effector memory CD4 Th1 cells after HIV infection is a key factor in the increased risk of active TB disease. Natural killer T cells are an innate type of immune cells responsible for first line of anti-viral defense, which may “jump-start” the adaptive immune responses and regulate the Th1 versus Th2 differentiation of CD4 helper T cells, through their unique ability to activate antigen-presenting cells (e.g., DCs). The regulatory...

Need for Greater Transparency in Enrollment in Drug Trials

submitted by: WentzMR

In an article appearing in the May 2013 issue of Mayo Clinic Proceedings, Dr. Mark A. Yarborough from the University of California, Davis, proposes the need to develop better disclosure, transparency, and measures of social value for persons recruited to participate in clinical research. Available at: http://tinyurl.com/d8appv7

Cardiovascular Fitness and Mortality After Contemporary Cardiac Rehabilitation

submitted by: WentzMR

Dr. James Stone, a Clinical Professor of Medicine at the University of Calgary, Canada, promotes the necessity, positive benefits, and overall mortality reduction with cardiac rehabilitation in patient with coronary artery disease as noted in their article appearing in the May 2013 issue of Mayo Clinic Proceedings. Available at: http://tinyurl.com/boopj26

Trust in Residents and Board Examinations: When Sharing Crosses the Boundary

submitted by: WentzMR
Dr. Gregory Ruhnke, an Assistant Professor in the Section of Hospital Medicine at the University of Chicago, in an article coauthored with Dr. David Doukas appearing in the May 2013 issue of Mayo Clinic Proceedings, examines the context and professional implications of residents preparing for board examinations using questions reproduced by previous residents. Available at: http://tinyurl.com/c5dhms6