Genome-wide association study of chronic periodontitis in a general German population

submitted by: ateumer
Aim: To identify loci associated with chronic periodontitis through a genome wide association study (GWAS). Materials and Methods: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n=3365 and SHIP-TREND n=667) with the different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genomes based...
Authors: A Teumer, B Holtfreter, U Völker, A Petersmann, M Nauck, R Biffar, H Völzke, HK Kroemer, P Meisel, G Homuth, T Kocher

Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical trial.

submitted by: rumoreno
AIM: To compare the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge carrier (ACS) with autogenous bone graft for augmentation of the edentulous atrophic anterior maxilla. METHODS: Twenty-four subjects were enrolled in a randomized, controlled, parallel-group, open-label clinical trial. Subjects either received rhBMP-2/ACS (1.5 mg/ml) or particulated autogenous bone harvested from the mandibular retromolar region. A titanium-mesh was used...
Authors: Rubens Freitas

Geospatial Exposure to Point-of-Sale Tobacco: Real-time craving and smoking-cessation outcomes

submitted by: tomkirchner
Background: Little is known about the factors that drive the association between point-of-sale marketing and behavior, because methods that directly link individual-level use outcomes to real-world point-of-sale exposure are only now beginning to be developed. Purpose: Daily outcomes during smoking cessation were examined as a function of both real-time geospatial exposure to point-of-sale tobacco (POST) and subjective craving to smoke. Methods: Continuous individual geospatial location data...
Authors: Thomas Kirchner, Jennifer Cantrell, Andrew Anesetti-Rothermel, Ollie Ganz, Donna Vallone, David Abrams

Sitting-Time, Physical Activity, and Depressive Symptoms in Mid-Aged Women

submitted by: jannique.van.uffelen
Background: Associations of sitting-time and physical activity with depression are unclear. Purpose: To examine concurrent and prospective associations between both sitting-time and physical activity with prevalent depressive symptoms in mid-aged Australian women. Methods: Data were from 8950 women, aged 50–55 years in 2001, who completed mail surveys in 2001, 2004, 2007, and 2010. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression questionnaire....
Authors: Jannique van Uffelen, Yolanda van Gellecum, Nicola Burton, Geeske Peeters, Kristiann Heesch, Wendy Brown

MWV Episode 76 - Jeffrey Almond - Vaccine Development

submitted by: MicrobeWorld
Dr. Jeffrey Almond began his career as an academic virologist studying influenza. Eventually Jeffrey started his own lab and began studying picornaviruses working on an oral polio vaccine strain. Following twenty years in academics including major contributions in the eradication of polio worldwide, Jeffrey transitioned into a career in industry working on vaccine development at Sanofi Pasteur. In March of 2013, Jeffrey was at the Society for General Microbiology's Spring conference to...

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen