BMI and all-cause mortality in older adults: a meta-analysis

submitted by: winterj
Background: Whether the association between body mass index (BMI) and all-cause mortality for older adults is the same as for younger adults is unclear. Objective: The objective was to determine the association between BMI and all-cause mortality risk in adults ?65 y of age. Design: A 2 stage random-effects meta-analysis was performed of studies published from 1990 to 2013 that reported the RRs of all-cause mortality for community-based adults aged ?65 y. Results: Thirty-two studies met...
Authors: Jane Winter, Robert MacInnis, Naiyana Wattanapenpaiboon, Caryl Nowson

Leipzig Loop Mitral Valve Repair

submitted by: mcgheek
This surgical video illustrates a minimally invasive approach to mitral valve repair--the Leipzig Loop technique. For more information, see Voiceover narration is provided by Mario Castillo-Sang, M.D., a cardiothoracice surgeon at the Medical University of South Carolina who specializes in minimally invasive mitral valve repair.

Repair of Degenerative Mitral Valve Regurgitation

submitted by: mcgheek
Video showing cases of mitral valve degeneration, before (via imaging used in diagnosis) and after repair using the minimally invasive Leipzig Loop technique. For more information, see the sister article "Restringing the Heart's Cords" at Voiceover narration is provided by Mario Castillo-Sang, M.D., a cardiothoracic surgeon at the Medical University of South Carolina who specializes in minimally invasive valve repair.

Making Muscle: Tissue Engineering in MUSC's Department of Surgery

submitted by: mcgheek
Samir Fakhry, M.D., Chief of MUSC's Division of General Surgery, and Michael Yost, PhD, Associate Chair of Research in MUSC's Department of Surgery, discuss the promise of engineered tissues for the treatment of surgical and trauma patients. Engineered tissue can instruct the body to regenerate native tissue instead of generating scar, improving cosmetic and functional outcomes. Bioprinters, 3D printers for living tissue, will help realize the promise of engineered tissue for clinical care.k

Congenital Heart Defects: Could the Developing Heart Hold the Key to New Therapies?

submitted by: mcgheek

Andrew M. Atz, M.D., Chief of the Division of Pediatric Cardiology at MUSC's Children's Hospital, and Kyu-Ho Lee, M.D., PhD, a developmental biologist at MUSC's Cardiovascular Developmental Biology Center, discuss how better understanding the gene signaling involved in the embryonic development of the heart could lead to new adjunctive therapies for congenital heart defects. Learn more about Dr. Lee's work in the November 2013 issue of Progressnotes at

Unrelated Donor Bone Marrow Transplant for Sickle Cell Disease

submitted by: mcgheek
Jennifer Jaroscak, M.D., of MUSC Children's Hospital discusses bone marrow transplant (BMT) as a cure for patients with sickle cell disease. She describes a new reduced-intensity conditioning (RIC) regimen being trialed at MUSC for BMTs from well-matched unrelated donors in the SCURT study. RIC is safer for unrelated donor transplant because, unlike myeloablative BMTs, it suppresses but does not destroy the patient's bone marrow. Find out more about the SCURT study and reduced-intensity...